Ascension Providence Hospital Scholarly Activity

     Research is an integral component of the Orthopaedic Surgery Residency program. Residents will have the opportunity to do case reports, retrospective studies (chart reviews), experimental studies (clinical trials, animal studies) and prospective studies. These studies can be developed with input from faculty, the Orthopaedic Research Laboratory Manager (Dr. Therese Bou-Akl), Biomedical Research department and fellow residents.
     Each year, a number of papers from the department are published in peer reviewed journals. Our residents present numerous oral papers and posters at local, regional, national and international meetings including Ascension Providence Hospital's Research Day, Southeast Michigan Center for Medical Education (SEMCME), the Michigan Orthopaedic Society, the American Academy of Orthopaedic Surgeons and the Orthopedic Research Society, among others. We are extremely proud of these accomplishments.
     A listing of our presentations (oral, video and poster formats), honors and recently published papers is shown below.

Recently Published Papers

  • Markel DC, Bergum C, Flynn J, Jackson N, Bou-Akl T, Ren W. Relationship of Blood Metal Ion Levels and Leukocyte Profiles in Patients With Articular Surface Replacement Metal-on-Metal Hip Replacement. Orthopedics, 41(May):e424-e431, 2018. PMID 29708567
  • Ren W, Song W, Yurgelevic S, Markel DC. Setting mechanism of a new injectable Dicalcium Phosphate Dihydrate (DCPD) forming cement. J Mech Behav Biomed Mater, 79(Mar):226-234, 2018. PMID 29331590
  • Song W, Seta J, Eichler MK, Arts JJ, Boszczyk BM, Markel DC, Gasbarrini A, Ren W. Comparison of in vitro biocompatibility of silicone and polymethyl methacrylate during the curing phase of polymerization. J Biomed Mater Res B Appl Biomater, 106(Oct):2693-2699, 2018.  PMID 29480542   
  • Yokhana SS, Bergum C, Ren W, Markel DC. Isolated Tibial Component Failure in Total Knee Arthroplasty: A Case Series Evaluating Inflammatory Response versus Mechanical Failure. J Knee Surg. 2018 (In press).   PMID 29991080   
  • Zhou Z, Seta J, Markel DC, Song W, Yurgelevic SM, Yu XW, Ren W. Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel. J Biomed Mater Res B Appl Biomater, 2018 (In press).  PMID 29282858
  • Courtney PM, Markel DC. Arthroplasty Registries: Improving Clinical and Economic Outcomes. J Knee Surg, 30(Jan):7-11, 2017.  PMID 27776373
  • Courtney PM, Huddleston JI, Iorio R, Markel DC. Socioeconomic Risk Adjustment Models for Reimbursement Are Necessary in Primary Total Joint Arthroplasty. J Arthroplasty, 32(Jan):1-5, 2017.  PMID 27506724
  • Karek MR, Jackson NM, Flynn JC, Vaidya R, Markel DC. Elution Profiles of Two Methods of Antibiotic Tibial Nail Preparations. Orthopedics, 40(May):e436-e442, 2017.  PMID 28135373
  • Markel DC, Allen MW, Hughes RE, Singal BM, Hallstrom BR. Quality Initiative Programs Can Decrease Total Joint Arthroplasty Transfusion Rates-A Multicenter Study Using the MARCQI Total Joint Registry Database. J Arthroplasty, 32(Nov):3292-3297, 2017.  PMID 28697866
  • Morris MR, Bergum C, Jackson N, Markel DC. Decreased Bacterial Adherence, Biofilm Formation, and Tissue Reactivity of Barbed Monofilament Suture in an In Vivo Contaminated Wound Model. J Arthroplasty, 32(Apr):1272-1279, 2017.  PMID 28065625
  • Sikora-Klak J, Zarling B, Bergum C, Flynn JC, Markel DC. The Effect of Comorbidities on Discharge Disposition and Readmission for Total Joint Arthroplasty Patients. J Arthroplasty, 32(May):1414-1417, 2017.  PMID 28041771
  • Sikora-Klak J, Gupta A, Bergum C, Zarling B, Markel DC. The Evaluation of Comorbidities Relative to Length of Stay for Total Joint Arthroplasty Patients. J Arthroplasty, 32(Apr):1085-1088, 2017.  PMID 28012724
  • Song W, Seta J, Chen L, Bergum C, Zhou Z, Kanneganti P, Kast RE, Auner GW, Shen M, Markel DC, Ren W, Yu X. Doxycycline-loaded coaxial nanofiber coating of titanium implants enhances osseointegration and inhibits Staphylococcus aureus infection. Biomed Mater, 12(Jul):045008, 2017.  PMID 28357996
  • Zarling BJ, Sikora-Klak J, Bergum C, Markel DC. How Do Preoperative Medications Influence Outcomes After Total Joint Arthroplasty? J Arthroplasty, 32(Sep):S259-S262, 2017.  PMID 28578845   
  • Allen, M. W., N. M. Zappa and D. C. Markel.  Can an Arthroplasty Registry Help Decrease Transfusions in Primary Total Joint Replacement? A Quality Initiative. Clinical Orthopaedics and Related Research, 474(Jan):126-131, 2016.  PMID 26215083
  • Chen, L., W. Song, D. C. Markel, T. Shi, O. Muzik, H. Matthew and W. Ren. Flow perfusion culture of MC3T3-E1 osteogenic cells on gradient calcium polyphosphate scaffolds with different pore sizes. Journal of Biomaterials Applications, 30 (Feb):908-918, 2016. PMID 26675750
  • Majewski RL, Zhang W, Ma X, Cui Z, Ren W, Markel DC. Bioencapsulation technologies in tissue engineering. J Appl Biomater Funct Mater, 14(Nov):e395-e403, 2016.  PMID 27716872 
  • Uchimura T, Foote AT, Markel DC, Ren W, Zeng L. The Chondroprotective Role of Erythromycin in a Murine Joint Destruction Model. Cartilage, 7(Oct):373-87, 2016.  PMID 27688845
  • Vigdorchik, J. M., A. M. Riesgo, D. Lincoln and D. C. Markel. Pulmonary Findings on Computed Tomography in Asymptomatic Total Joint Arthroplasty Patients. Journal of Knee Surgery, 29(Aug):478-481, 2016.  PMID 26551068
  • Zarling BJ, Yokhana SS, Herzog DT, Markel DC. Preoperative and Postoperative Opiate Use by the Arthroplasty Patient. J Arthroplasty, 31(Oct):2081-2084, 2016.  PMID 27161903
  • Cook, G. E., D. C. Markel, W. Ren, L. X. Webb, M. D. McKee and E. H. Schemitsch.  Infection in Orthopaedics. Journal of Orthopaedic Trauma, 29(Dec suppl 12):S19-23, 2015.  PMID 26584261
  • Loving, L., L. Herrera, S. Banerjee, C. Heffernan, J. Nevelos, D. C. Markel and M. A. Mont. Dual mobility bearings withstand loading from steeper cup-inclinations without substantial wear. Journal of Orthopaedic Research, 33(Mar):398-404, 2015.  PMID 25421305
  • Vigdorchik, J. M., M. R. D'Apuzzo, D. C. Markel, A. L. Malkani, S. Raterman, K. P. Sharpe, C. N. Cornell and G. H. Westrich. Lack of early dislocation following total hip arthroplasty with a new dual mobility acetabular design. Hip International, 25(Jan):34-38, 2015.  PMID 25655740
  • Walsh, C. P., J. C. Hubbard, J. P. Nessler and D. C. Markel. MRI Findings Associated with Recalled Modular Femoral Neck Rejuvenate and ABG Implants. Journal of Arthroplasty, 30(Nov):2021-2026, 2015.  PMID 26122109
  • Walsh, C. P., J. C. Hubbard, J. P. Nessler and D. C. Markel. Revision of Recalled Modular Neck Rejuvenate and ABG Femoral Implants. Journal of Arthroplasty, 30(May):822-826, 2015.  PMID 25573180
  • Heffernan, C., S. Banerjee, J. Nevelos, J. Macintyre, K. Issa, D. C. Markel and M. A. Mont. Does dual-mobility cup geometry affect posterior horizontal dislocation distance?  Clinical Orthopaedics and Related Research, 472(May):1535-1544, 2014.  PMID 24464508
  • Jaafar, S., J. Vigdorchik and D. C. Markel. Drain technique in elective total joint Arthroplasty. Orthopedics, 37(Jan):37-39, 2014.  PMID 24683648
  • Markel, D. C., N. M. Jackson, A. O Esquivel, W. Ren and J. C. Flynn. Immunological response to bolus versus multiple injections of hylan G-F 20 (Synvisc) in a murine biocompatibility model. Journal of Biomedical Materials Research: Part B, Applied Biomaterials, 102(Oct):1375-1380, 2014.  PMID 24500880
  • Ren, W., N. Jackson, W. Song, T. Shi, J. C. Flynn and D. C. Markel. Implant wear induced inflammation is mitigated in CX3CR1(-/-) mice. Journal of Orthopaedic Research, 32(Aug):1037-1043, 2014.  PMID 24700421
  • Ren, W. P., W. Song, A. O. Esquivel, N. M. Jackson, M. Nelson, J. C. Flynn and D. C. Markel. Effect of erythromycin-doped calcium polyphosphate scaffold composite in a mouse pouch infection model. Journal of Biomedical Materials Research: Part B, Applied Biomaterials, 102(Jun):1140-1147, 2014. PMID 24347324
  • Shen, Y., W. Wang W., X. Li, D. C. Markel and W. Ren.  Mitigative effect of erythromycin on PMMA challenged preosteoblastic MC3T3-E1 cells. Scientific World Journal, 2014:107196, 2014.  PMID 25110723